학술논문

Improving rigor and reproducibility in nonhuman primate research.
Document Type
article
Source
American journal of primatology. 83(12)
Subject
National Primate Research Center Consortium Rigor and Reproducibility Working Group
Animals
Primates
Disease Models
Animal
Reproducibility of Results
Biomedical Research
biomedical research
data sharing
nonhuman primates
preregistration
quality assurance
Infectious Diseases
Good Health and Well Being
Zoology
Anthropology
Behavioral Science & Comparative Psychology
Language
Abstract
Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Here, we discuss a number of approaches that collectively can contribute to enhanced rigor and reproducibility in NHP research.