학술논문

Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
Document Type
article
Source
Open Forum Infectious Diseases. 8(8)
Subject
Biomedical and Clinical Sciences
Immunology
Pneumonia & Influenza
Biotechnology
Lung
Infectious Diseases
Prevention
Rare Diseases
Immunization
Clinical Research
Pneumonia
Emerging Infectious Diseases
Vaccine Related
Biodefense
Inflammatory and immune system
Infection
Good Health and Well Being
COVID-19 vaccine
neutralizing antibodies
rheumatological disease
SARS-CoV-2
T-cell immunity
Clinical sciences
Medical microbiology
Language
Abstract
We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.