학술논문

Impact of age on treatment response in men with prostate cancer treated with radiotherapy
Document Type
article
Source
BJUI Compass. 3(3)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Oncology and Carcinogenesis
Urologic Diseases
Aging
Cancer
Prostate Cancer
Clinical Research
Good Health and Well Being
hormone receptor agonists
neoadjuvant therapy
prostatic neoplasm
radiotherapy
veterans
Clinical sciences
Language
Abstract
ObjectiveTo analyse the effect of age at diagnosis on clinical outcomes of localized prostate cancer (PCa) treated with radiation therapy.Subjects and methodsWe identified 12 784 patients with intermediate- or high-risk localized PCa treated with radiation therapy (RT) and neoadjuvant androgen deprivation therapy (ADT) between 2000 and 2015 from nationwide Veterans Affairs data. Patients were grouped into three age categories (≤59, 60-69, and ≥70 years old). Outcomes included immediate PSA response (3-month post-RT PSA and 2-year PSA nadir, grouped into