학술논문
A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD
Document Type
article
Author
Jain, M; Vélez, JI; Acosta, MT; Palacio, LG; Balog, J; Roessler, E; Pineda, D; Londoño, AC; Palacio, JD; Arbelaez, A; Lopera, F; Elia, J; Hakonarson, H; Seitz, C; Freitag, CM; Palmason, H; Meyer, J; Romanos, M; Walitza, S; Hemminger, U; Warnke, A; Romanos, J; Renner, T; Jacob, C; Lesch, K-P; Swanson, J; Castellanos, FX; Bailey-Wilson, JE; Arcos-Burgos, M; Muenke, M
Source
Molecular Psychiatry. 17(7)
Subject
Language
Abstract
In previous studies of a genetic isolate, we identified significant linkage of attention deficit hyperactivity disorder (ADHD) to 4q, 5q, 8q, 11q and 17p. The existence of unique large size families linked to multiple regions, and the fact that these families came from an isolated population, we hypothesized that two-locus interaction contributions to ADHD were plausible. Several analytical models converged to show significant interaction between 4q and 11q (P