학술논문

Promises and challenges of personalized medicine to guide ARDS therapy
Document Type
article
Source
Critical Care. 25(1)
Subject
Rare Diseases
Lung
Acute Respiratory Distress Syndrome
Good Health and Well Being
COVID-19
Clinical Trials as Topic
Humans
Precision Medicine
Respiratory Distress Syndrome
Acute respiratory distress syndrome
Acute lung injury
Personalized medicine
Clinical trials
Medical and Health Sciences
Emergency & Critical Care Medicine
Language
Abstract
Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the importance of the global context to identify effective ARDS treatments. This review highlights emerging opportunities and continued challenges for personalizing therapy for ARDS, from identifying treatable traits to innovative clinical trial design and recognition of patient-level factors as the field of critical care investigation moves forward into the twenty-first century.