학술논문
Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1
Document Type
article
Author
Ustun, Celalettin; Kim, Soyoung; Chen, Min; Beitinjaneh, Amer M; Brown, Valerie I; Dahi, Parastoo B; Daly, Andrew; Diaz, Miguel Angel; Freytes, Cesar O; Ganguly, Siddhartha; Hashmi, Shahrukh; Hildebrandt, Gerhard C; Lazarus, Hillard M; Nishihori, Taiga; Olsson, Richard F; Page, Kristin M; Papanicolaou, Genovefa; Saad, Ayman; Seo, Sachiko; William, Basem M; Wingard, John R; Wirk, Baldeep; Yared, Jean A; Perales, Miguel-Angel; Auletta, Jeffery J; Komanduri, Krishna V; Lindemans, Caroline A; Riches, Marcie L
Source
Blood Advances. 3(17)
Subject
Language
Abstract
Presumably, reduced-intensity/nonmyeloablative conditioning (RIC/NMA) for allogeneic hematopoietic cell transplantation (alloHCT) results in reduced infections compared with myeloablative conditioning (MAC) regimens; however, published evidence is limited. In this Center for International Blood and Marrow Transplant Research study, 1755 patients (aged ≥40 years) with acute myeloid leukemia in first complete remission were evaluated for infections occurring within 100 days after T-cell replete alloHCT. Patients receiving RIC/NMA (n = 777) compared with those receiving MAC (n = 978) were older and underwent transplantation more recently; however, the groups were similar regarding Karnofsky performance score, HCT-comorbidity index, and cytogenetic risk. One or more infections occurred in 1045 (59.5%) patients (MAC, 595 [61%]; RIC/NMA, 450 [58%]; P = .21) by day 100. The median time to initial infection after MAC conditioning occurred earlier (MAC, 15 days [range,