학술논문
Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Document Type
article
Author
Yarchoan, Mark; Agarwal, Parul; Villanueva, Augusto; Rao, Shuyun; Dawson, Laura A; Karasic, Thomas; Llovet, Josep M; Finn, Richard S; Groopman, John D; El-Serag, Hashem B; Monga, Satdarshan P; Wang, Xin Wei; Karin, Michael; Schwartz, Robert E; Tanabe, Kenneth K; Roberts, Lewis R; Gunaratne, Preethi H; Tsung, Allan; Brown, Kimberly A; Lawrence, Theodore S; Salem, Riad; Singal, Amit G; Kim, Amy K; Rabiee, Atoosa; Resar, Linda; Meyer, Jeffrey; Hoshida, Yujin; He, Aiwu Ruth; Ghoshal, Kalpana; Ryan, Patrick B; Jaffee, Elizabeth M; Guha, Chandan; Mishra, Lopa; Coleman, C Norman; Ahmed, Mansoor M
Source
Cancer Research. 79(17)
Subject
Language
Abstract
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer deaths globally. The landscape of systemic therapy has recently changed, with six additional systemic agents either approved or awaiting approval for advanced stage HCC. While these agents have the potential to improve outcomes, a survival increase of 2-5 months remains poor and falls short of what has been achieved in many other solid tumor types. The roles of genomics, underlying cirrhosis, and optimal use of treatment strategies that include radiation, liver transplantation, and surgery remain unanswered. Here, we discuss new treatment opportunities, controversies, and future directions in managing HCC.