학술논문
A standard calculation methodology for human doubly labeled water studies.
Document Type
article
Author
Speakman, John R; Yamada, Yosuke; Sagayama, Hiroyuki; Berman, Elena SF; Ainslie, Philip N; Andersen, Lene F; Anderson, Liam J; Arab, Lenore; Baddou, Issaad; Bedu-Addo, Kweku; Blaak, Ellen E; Blanc, Stephane; Bonomi, Alberto G; Bouten, Carlijn VC; Bovet, Pascal; Buchowski, Maciej S; Butte, Nancy F; Camps, Stefan GJA; Close, Graeme L; Cooper, Jamie A; Creasy, Seth A; Das, Sai Krupa; Cooper, Richard; Dugas, Lara R; Ebbeling, Cara B; Ekelund, Ulf; Entringer, Sonja; Forrester, Terrence; Fudge, Barry W; Goris, Annelies H; Gurven, Michael; Hambly, Catherine; El Hamdouchi, Asmaa; Hoos, Marije B; Hu, Sumei; Joonas, Noorjehan; Joosen, Annemiek M; Katzmarzyk, Peter; Kempen, Kitty P; Kimura, Misaka; Kraus, William E; Kushner, Robert F; Lambert, Estelle V; Leonard, William R; Lessan, Nader; Ludwig, David S; Martin, Corby K; Medin, Anine C; Meijer, Erwin P; Morehen, James C; Morton, James P; Neuhouser, Marian L; Nicklas, Theresa A; Ojiambo, Robert M; Pietiläinen, Kirsi H; Pitsiladis, Yannis P; Plange-Rhule, Jacob; Plasqui, Guy; Prentice, Ross L; Rabinovich, Roberto A; Racette, Susan B; Raichlen, David A; Ravussin, Eric; Reynolds, Rebecca M; Roberts, Susan B; Schuit, Albertine J; Sjödin, Anders M; Stice, Eric; Urlacher, Samuel S; Valenti, Giulio; Van Etten, Ludo M; Van Mil, Edgar A; Wells, Jonathan CK; Wilson, George; Wood, Brian M; Yanovski, Jack; Yoshida, Tsukasa; Zhang, Xueying; Murphy-Alford, Alexia J; Loechl, Cornelia U; Melanson, Edward L; Luke, Amy H; Pontzer, Herman; Rood, Jennifer; Schoeller, Dale A; Westerterp, Klaas R; Wong, William W; IAEA DLW database group
Source
Cell reports. Medicine. 2(2)
Subject
Language
Abstract
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (