학술논문
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
Document Type
article
Author
Malhotra, Rajeev; Mauer, Andreas C; Lino Cardenas, Christian L; Guo, Xiuqing; Yao, Jie; Zhang, Xiaoling; Wunderer, Florian; Smith, Albert V; Wong, Quenna; Pechlivanis, Sonali; Hwang, Shih-Jen; Wang, Judy; Lu, Lingyi; Nicholson, Christopher J; Shelton, Georgia; Buswell, Mary D; Barnes, Hanna J; Sigurslid, Haakon H; Slocum, Charles; Rourke, Caitlin O’; Rhee, David K; Bagchi, Aranya; Nigwekar, Sagar U; Buys, Emmanuel S; Campbell, Catherine Y; Harris, Tamara; Budoff, Matthew; Criqui, Michael H; Rotter, Jerome I; Johnson, Andrew D; Song, Ci; Franceschini, Nora; Debette, Stephanie; Hoffmann, Udo; Kälsch, Hagen; Nöthen, Markus M; Sigurdsson, Sigurdur; Freedman, Barry I; Bowden, Donald W; Jöckel, Karl-Heinz; Moebus, Susanne; Erbel, Raimund; Feitosa, Mary F; Gudnason, Vilmundur; Thanassoulis, George; Zapol, Warren M; Lindsay, Mark E; Bloch, Donald B; Post, Wendy S; O’Donnell, Christopher J
Source
Nature Genetics. 51(11)
Subject
Language
Abstract
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P