학술논문

Software and methods for oligonucleotide and cDNA array data analysis
Document Type
article
Source
Genome Biology. 3(6)
Subject
Biological Sciences
Bioinformatics and Computational Biology
Genetics
Computational Biology
DNA
Complementary
Database Management Systems
Databases
Genetic
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
Oligonucleotides
Software
Environmental Sciences
Information and Computing Sciences
Bioinformatics
Language
Abstract
Two HTML-based programs were developed to analyze and filter gene-expression data: 'Bullfrog' for Affymetrix oligonucleotide arrays and 'Spot' for custom cDNA arrays. The programs provide intuitive data-filtering tools through an easy-to-use interface. A background subtraction and normalization program for cDNA arrays was also built that provides an informative summary report with data-quality assessments. These programs are freeware to aid in the analysis of gene-expression results and facilitate the search for genes responsible for interesting biological processes and phenotypes.