학술논문
Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study
Document Type
article
Author
Hart, Phil A; Papachristou, Georgios I; Park, Walter G; Dyer, Anne-Marie; Chinchilli, Vernon M; Afghani, Elham; Akshintala, Venkata S; Andersen, Dana K; Buxbaum, James L; Conwell, Darwin L; Dungan, Kathleen M; Easler, Jeffrey J; Fogel, Evan L; Greenbaum, Carla J; Kalyani, Rita R; Korc, Murray; Kozarek, Richard; Laughlin, Maren R; Lee, Peter J; Maranki, Jennifer L; Pandol, Stephen J; Phillips, Anna Evans; Serrano, Jose; Singh, Vikesh K; Speake, Cate; Tirkes, Temel; Toledo, Frederico GS; Trikudanathan; Vege, Santhi Swaroop; Wang, Ming; Yazici, Cemal; Zaheer, Atif; Forsmark, Christopher E; Bellin, Melena D; Yadav, Dhiraj
Source
Pancreas. 51(6)
Subject
Language
Abstract
AbstractAcute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.