학술논문

Military risk factors for Alzheimer's disease.
Document Type
article
Source
Alzheimer's & dementia : the journal of the Alzheimer's Association. 9(4)
Subject
Humans
Brain Damage
Chronic
Brain Injuries
Alzheimer Disease
Blast Injuries
Early Diagnosis
Risk Factors
Stress Disorders
Post-Traumatic
Military Medicine
United States Department of Veterans Affairs
Government Programs
Databases
Factual
Military Personnel
United States
Multicenter Studies as Topic
Afghan Campaign 2001-
Veterans Health
United States Department of Defense
Neuroimaging
Iraq War
2003-2011
Biomarkers
National Institute of Neurological Disorders and Stroke (U.S.)
Prevention
Alzheimer's Disease
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Biomedical Imaging
Clinical Research
Acquired Cognitive Impairment
Brain Disorders
Dementia
Neurosciences
Aging
Neurodegenerative
4.1 Discovery and preclinical testing of markers and technologies
Detection
screening and diagnosis
Neurological
Anxiety Disorders
Mental Health
Traumatic Brain Injury (TBI)
Post-Traumatic Stress Disorder (PTSD)
Physical Injury - Accidents and Adverse Effects
Traumatic Head and Spine Injury
Injuries and accidents
Good Health and Well Being
Alzheimer's disease
Risk factors
Military medicine
Traumatic brain injury
Posttraumatie stress disorder
Tau
Beta-amyloid
Apolipoprotein E e4
Alzheimer's Disease Neuroimaging Initiative
Vietnam
Veterans
Chronic traumatic encephalopathy
Blast injury
Clinical Sciences
Geriatrics
Language
Abstract
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.