학술논문
Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics
Document Type
article
Author
Ostrom, Quinn T; Egan, Kathleen M; Nabors, L Burt; Gerke, Travis; Thompson, Reid C; Olson, Jeffrey J; LaRocca, Renato; Chowdhary, Sajeel; Eckel‐Passow, Jeanette E; Armstrong, Georgina; Wiencke, John K; Bernstein, Jonine L; Claus, Elizabeth B; Il'yasova, Dora; Johansen, Christoffer; Lachance, Daniel H; Lai, Rose K; Merrell, Ryan T; Olson, Sara H; Sadetzki, Siegal; Schildkraut, Joellen M; Shete, Sanjay; Houlston, Richard S; Jenkins, Robert B; Wrensch, Margaret R; Melin, Beatrice; Amos, Christopher I; Huse, Jason T; Barnholtz‐Sloan, Jill S; Bondy, Melissa L
Source
International Journal of Cancer. 146(3)
Subject
Language
Abstract
Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). It is unknown if identified GWAS loci or increased EA is associated with increased glioma risk. We assessed whether EA was associated with glioma in African Americans and Hispanics. Data were obtained for 832 cases and 675 controls from the Glioma International Case-Control Study and GliomaSE Case-Control Study previously estimated to have