학술논문
Genome-Wide Interaction Analysis of Menopausal Hormone Therapy Use and Breast Cancer Risk Among 62,370 Women
Document Type
article
Author
Wang, Xiaoliang; Kapoor, Pooja Middha; Auer, Paul L; Dennis, Joe; Dunning, Alison M; Wang, Qin; Lush, Michael; Michailidou, Kyriaki; Bolla, Manjeet K; Aronson, Kristan J; Murphy, Rachel A; Brooks-Wilson, Angela; Lee, Derrick G; Cordina-Duverger, Emilie; Guénel, Pascal; Truong, Thérèse; Mulot, Claire; Teras, Lauren R; Patel, Alpa V; Dossus, Laure; Kaaks, Rudolf; Hoppe, Reiner; Lo, Wing-Yee; Brüning, Thomas; Hamann, Ute; Czene, Kamila; Gabrielson, Marike; Hall, Per; Eriksson, Mikael; Jung, Audrey; Becher, Heiko; Couch, Fergus J; Larson, Nicole L; Olson, Janet E; Ruddy, Kathryn J; Giles, Graham G; MacInnis, Robert J; Southey, Melissa C; Marchand, Loic Le; Wilkens, Lynne R; Haiman, Christopher A; Olsson, Håkan; Augustinsson, Annelie; Krüger, Ute; Wagner, Philippe; Scott, Christopher; Winham, Stacey J; Vachon, Celine M; Perou, Charles M; Olshan, Andrew F; Troester, Melissa A; Hunter, David J; Eliassen, A Heather; Tamimi, Rulla M; Brantley, Kristen; Andrulis, Irene L; Figueroa, Jonine; Chanock, Stephen J; Ahearn, Thomas U; García-Closas, Montserrat; Evans, Gareth D; Newman, William G; Veen, Elke M van; Howell, Anthony; Wolk, Alicja; Håkansson, Niclas; Anton-Culver, Hoda; Ziogas, Argyrios; Jones, Michael E; Orr, Nick; Schoemaker, Minouk J; Swerdlow, Anthony J; Kitahara, Cari M; Linet, Martha; Prentice, Ross L; Easton, Douglas F; Milne, Roger L; Kraft, Peter; Chang-Claude, Jenny; Lindström, Sara
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Abstract
Abstract Background: Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. Methods: We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values