학술논문
Genome‐Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
Document Type
article
Author
Smith, Caren E; Follis, Jack L; Dashti, Hassan S; Tanaka, Toshiko; Graff, Mariaelisa; Fretts, Amanda M; Kilpeläinen, Tuomas O; Wojczynski, Mary K; Richardson, Kris; Nalls, Mike A; Schulz, Christina‐Alexandra; Liu, Yongmei; Frazier‐Wood, Alexis C; van Eekelen, Esther; Wang, Carol; de Vries, Paul S; Mikkilä, Vera; Rohde, Rebecca; Psaty, Bruce M; Hansen, Torben; Feitosa, Mary F; Lai, Chao‐Qiang; Houston, Denise K; Ferruci, Luigi; Ericson, Ulrika; Wang, Zhe; de Mutsert, Renée; Oddy, Wendy H; de Jonge, Ester AL; Seppälä, Ilkka; Justice, Anne E; Lemaitre, Rozenn N; Sørensen, Thorkild IA; Province, Michael A; Parnell, Laurence D; Garcia, Melissa E; Bandinelli, Stefania; Orho‐Melander, Marju; Rich, Stephen S; Rosendaal, Frits R; Pennell, Craig E; Jong, Jessica C Kiefte‐de; Kähönen, Mika; Young, Kristin L; Pedersen, Oluf; Aslibekyan, Stella; Rotter, Jerome I; Mook‐Kanamori, Dennis O; Zillikens, M Carola; Raitakari, Olli T; North, Kari E; Overvad, Kim; Arnett, Donna K; Hofman, Albert; Lehtimäki, Terho; Tjønneland, Anne; Uitterlinden, André G; Rivadeneira, Fernando; Franco, Oscar H; German, J Bruce; Siscovick, David S; Cupples, L Adrienne; Ordovás, José M
Source
Molecular Nutrition & Food Research. 62(3)
Subject
Language
Abstract
ScopeBody weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.Methods and resultsA genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction