학술논문
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York
Document Type
article
Author
West, Anthony P; Wertheim, Joel O; Wang, Jade C; Vasylyeva, Tetyana I; Havens, Jennifer L; Chowdhury, Moinuddin A; Gonzalez, Edimarlyn; Fang, Courtney E; Di Lonardo, Steve S; Hughes, Scott; Rakeman, Jennifer L; Lee, Henry H; Barnes, Christopher O; Gnanapragasam, Priyanthi NP; Yang, Zhi; Gaebler, Christian; Caskey, Marina; Nussenzweig, Michel C; Keeffe, Jennifer R; Bjorkman, Pamela J
Source
bioRxiv. 2(04-27)
Subject
Language
Abstract
Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. Variants first detected in the United Kingdom, South Africa, and Brazil have spread to multiple countries. We developed the software tool, Variant Database (VDB), for quickly examining the changing landscape of spike mutations. Using VDB, we detected an emerging lineage of SARS-CoV-2 in the New York region that shares mutations with previously reported variants. The most common sets of spike mutations in this lineage (now designated as B.1.526) are L5F, T95I, D253G, E484K or S477N, D614G, and A701V. This lineage was first sequenced in late November 2020 when it represented