학술논문
Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Childrens Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials.
Document Type
article
Author
Liu, Anthony; Dhanda, Sandeep; Lin, Tong; Sioson, Edgar; Vasilyeva, Aksana; Gudenas, Brian; Tatevossian, Ruth; Jia, Sujuan; Neale, Geoffrey; Bowers, Daniel; Hassall, Tim; Partap, Sonia; Crawford, John; Chintagumpala, Murali; Bouffet, Eric; McCowage, Geoff; Broniscer, Alberto; Qaddoumi, Ibrahim; Armstrong, Greg; Wright, Karen; Upadhyaya, Santhosh; Vinitsky, Anna; Tinkle, Christopher; Lucas, John; Chiang, Jason; Indelicato, Daniel; Sanders, Robert; Klimo, Paul; Boop, Frederick; Merchant, Thomas; Ellison, David; Northcott, Paul; Orr, Brent; Zhou, Xin; Onar-Thomas, Arzu; Gajjar, Amar; Robinson, Giles
Source
Acta Neuropathologica. 144(4)
Subject
Language
Abstract
Methylation profiling has radically transformed our understanding of tumors previously called central nervous system primitive neuro-ectodermal tumors (CNS-PNET). While this marks a momentous step toward defining key differences, reclassification has thrown treatment into disarray. To shed light on response to therapy and guide clinical decision-making, we report outcomes and molecular features of children with CNS-PNETs from two multi-center risk-adapted studies (SJMB03 for patients ≥ 3 years; SJYC07 for patients