학술논문

Diagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016

Document Type

article

Author

Chiu, Charles Y; Coffey, Lark L; Murkey, Jamie; Symmes, Kelly; Sample, Hannah A; Wilson, Michael R; Naccache, Samia N; Arevalo, Shaun; Somasekar, Sneha; Federman, Scot; Stryke, Doug; Vespa, Paul; Schiller, Gary; Messenger, Sharon; Humphries, Romney; Miller, Steve; Klausner, Jeffrey D

Source

Emerging Infectious Diseases. 23(10)

Subject

Biomedical and Clinical Sciences
Clinical Sciences
Infectious Diseases
Clinical Research
Brain Disorders
Aetiology
2.1 Biological and endogenous factors
Infection
Good Health and Well Being
Aged
Bronchopneumonia
California
Encephalitis Virus
St. Louis
Encephalitis
St. Louis
Fatal Outcome
Genome
Viral
High-Throughput Nucleotide Sequencing
Humans
Lymphoma
Mantle-Cell
Male
Metagenome
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction
SLEV
St. Louis encephalitis virus
United States
West Nile virus
Zika virus
arboviruses
flavivirus infections
mNGS
meningitis/encephalitis
metagenomic next-generation sequencing
mosquitoborne infections
outbreak surveillance
vector-borne infections
viruses
whole-genome viral sequencing
Medical Microbiology
Public Health and Health Services
Microbiology
Clinical sciences
Epidemiology
Health services and systems

Language

Abstract

We used unbiased metagenomic next-generation sequencing to diagnose a fatal case of meningoencephalitis caused by St. Louis encephalitis virus in a patient from California in September 2016. This case is associated with the recent 2015-2016 reemergence of this virus in the southwestern United States.

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