학술논문
Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial
Document Type
article
Author
Source
Muscle & Nerve. 58(1)
Subject
Language
Abstract
INTRODUCTION:More than 90% of amyotrophic lateral sclerosis (ALS) patients have muscle cramps, but evidence-based treatments have not been available.METHODS:A multicenter, double-blind, placebo-controlled crossover trial of mexiletine 150 mg twice daily was conducted in ALS patients requesting treatment of symptomatic muscle cramps.RESULTS:Muscle cramp frequency was reduced in 18 of 20 patients; 13 reductions were attributed to treatment (P