학술논문
Accelerating precision medicine in metastatic prostate cancer
Document Type
article
Author
Mateo, Joaquin; McKay, Rana; Abida, Wassim; Aggarwal, Rahul; Alumkal, Joshi; Alva, Ajjai; Feng, Felix; Gao, Xin; Graff, Julie; Hussain, Maha; Karzai, Fatima; Montgomery, Bruce; Oh, William; Patel, Vaibhav; Rathkopf, Dana; Rettig, Matthew; Schultz, Nikolaus; Smith, Matthew; Solit, David; Sternberg, Cora; Van Allen, Eliezer; VanderWeele, David; Vinson, Jake; Soule, Howard R; Chinnaiyan, Arul; Small, Eric; Simons, Jonathan W; Dahut, William; Miyahira, Andrea K; Beltran, Himisha
Source
Nature Cancer. 1(11)
Subject
Language
Abstract
Despite advances in prostate cancer screening and treatment, available therapy options, particularly in later stages of the disease, remain limited and the treatment-resistant setting represents a serious unmet medical need. Moreover, disease heterogeneity and disparities in patient access to medical advances result in significant variability in outcomes across patients. Disease classification based on genomic sequencing is a promising approach to identify patients whose tumors exhibit actionable targets and make more informed treatment decisions. Here we discuss how we can accelerate precision oncology to inform broader genomically-driven clinical decisions for men with advanced prostate cancer, drug development and ultimately contribute to new treatment paradigms.