학술논문
Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors
Document Type
article
Author
Chang, Timothy S; Ding, Yi; Freund, Malika K; Johnson, Ruth; Schwarz, Tommer; Yabu, Julie M; Hazlett, Chad; Chiang, Jeffrey N; Wulf, David A; Group, UCLA Precision Health Data Discovery Repository Working; Antonio, Anna L; Ariannejad, Maryam; Badillo, Angela M; Balliu, Brunilda; Berkovich, Yael; Broudy, Michael; Dang, Tony; Denny, Chris; Eskin, Eleazar; Halperin, Eran; Hill, Brian L; Jain, Ankur; Katakwar, Vivek; Lajonchere, Clara; Magyar, Clara; Minton, Sheila; Mohammed, Ghouse; Muhamed, Ariff; Pavan, Pabba; Pfeffer, Michael A; Rakocz, Nadav; Rudas, Akos; Salonga, Rey; Sanders, Timothy J; Tung, Paul; Vu, Vu; Zheng, Ailsa; Geschwind, Daniel H; Butte, Manish J; Pasaniuc, Bogdan
Source
iScience. 24(3)
Subject
Language
Abstract
Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9, 2020, and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor for HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.