학술논문
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies
Document Type
article
Author
Watts, Eleanor L; Perez‐Cornago, Aurora; Appleby, Paul N; Albanes, Demetrius; Ardanaz, Eva; Black, Amanda; Bueno‐de‐Mesquita, H Bas; Chan, June M; Chen, Chu; Chubb, SA Paul; Cook, Michael B; Deschasaux, Mélanie; Donovan, Jenny L; English, Dallas R; Flicker, Leon; Freedman, Neal D; Galan, Pilar; Giles, Graham G; Giovannucci, Edward L; Gunter, Marc J; Habel, Laurel A; Häggström, Christel; Haiman, Christopher; Hamdy, Freddie C; Hercberg, Serge; Holly, Jeff M; Huang, Jiaqi; Huang, Wen‐Yi; Johansson, Mattias; Kaaks, Rudolf; Kubo, Tatsuhiko; Lane, J Athene; Layne, Tracy M; Le Marchand, Loic; Martin, Richard M; Metter, E Jeffrey; Mikami, Kazuya; Milne, Roger L; Morris, Howard A; Mucci, Lorelei A; Neal, David E; Neuhouser, Marian L; Oliver, Steven E; Overvad, Kim; Ozasa, Kotaro; Pala, Valeria; Pernar, Claire H; Pollak, Michael; Rowlands, Mari‐Anne; Schaefer, Catherine A; Schenk, Jeannette M; Stattin, Pär; Tamakoshi, Akiko; Thysell, Elin; Touvier, Mathilde; Trichopoulou, Antonia; Tsilidis, Konstantinos K; Van Den Eeden, Stephen K; Weinstein, Stephanie J; Wilkens, Lynne; Yeap, Bu B; Key, Timothy J; Allen, Naomi E; Travis, Ruth C
Source
International Journal of Cancer. 145(12)
Subject
Language
Abstract
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.