학술논문
Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies
Document Type
article
Author
Watts, Eleanor L; Appleby, Paul N; Perez-Cornago, Aurora; Bueno-de-Mesquita, H Bas; Chan, June M; Chen, Chu; Cohn, Barbara A; Cook, Michael B; Flicker, Leon; Freedman, Neal D; Giles, Graham G; Giovannucci, Edward; Gislefoss, Randi E; Hankey, Graeme J; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurence N; Kubo, Tatsuhiko; Le Marchand, Loïc; Luben, Robert N; Luostarinen, Tapio; Männistö, Satu; Metter, E Jeffrey; Mikami, Kazuya; Milne, Roger L; Ozasa, Kotaro; Platz, Elizabeth A; Quirós, J Ramón; Rissanen, Harri; Sawada, Norie; Stampfer, Meir; Stanczyk, Frank Z; Stattin, Pär; Tamakoshi, Akiko; Tangen, Catherine M; Thompson, Ian M; Tsilidis, Konstantinos K; Tsugane, Shoichiro; Ursin, Giske; Vatten, Lars; Weiss, Noel S; Yeap, Bu B; Allen, Naomi E; Key, Timothy J; Travis, Ruth C
Source
European Urology. 74(5)
Subject
Language
Abstract
BackgroundExperimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting.ObjectiveTo examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer.Design, setting, and participantsAnalysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group.Outcome measurements and statistical analysisOdds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration.Results and limitationsMen in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR=0.77, 95% confidence interval [CI] 0.69-0.86; p