부산대학교 도서관

Tourette Syndrome is a heritable neurodevelopmental disorder whose pathophysiology remainsunknown. Recent genomewide association studies suggest that it is a polygenic disorderinfluenced by many genes of small effect. We tested whether these genes cluster in cellularfunction by applying gene‐set analyses using expert curated sets of brain‐expressed genes in thecurrent largest available Tourette Syndrome genome‐wide association dataset, involving 1285cases and 4964 controls. The gene‐sets included specific synaptic, astrocytic, oliogodendrocyteand microglial functions. We report association of Tourette Syndrome with a set of genesinvolved in astrocyte function, specifically in astrocyte carbohydrate metabolism. Thisassociation is driven primarily by a subset of 33 genes involved in glycolysis and glutamatemetabolism through which astrocytes support synaptic function. Our results indicate for the firsttime that the process of astrocyte‐neuron metabolic coupling may be an important contributorto Tourette Syndrome pathogenesis.