학술논문
Daily energy expenditure through the human life course
Document Type
article
Author
Pontzer, Herman; Yamada, Yosuke; Sagayama, Hiroyuki; Ainslie, Philip N; Andersen, Lene F; Anderson, Liam J; Arab, Lenore; Baddou, Issaad; Bedu-Addo, Kweku; Blaak, Ellen E; Blanc, Stephane; Bonomi, Alberto G; Bouten, Carlijn VC; Bovet, Pascal; Buchowski, Maciej S; Butte, Nancy F; Camps, Stefan G; Close, Graeme L; Cooper, Jamie A; Cooper, Richard; Das, Sai Krupa; Dugas, Lara R; Ekelund, Ulf; Entringer, Sonja; Forrester, Terrence; Fudge, Barry W; Goris, Annelies H; Gurven, Michael; Hambly, Catherine; Hamdouchi, Asmaa El; Hoos, Marjije B; Hu, Sumei; Joonas, Noorjehan; Joosen, Annemiek M; Katzmarzyk, Peter; Kempen, Kitty P; Kimura, Misaka; Kraus, William E; Kushner, Robert F; Lambert, Estelle V; Leonard, William R; Lessan, Nader; Martin, Corby; Medin, Anine C; Meijer, Erwin P; Morehen, James C; Morton, James P; Neuhouser, Marian L; Nicklas, Teresa A; Ojiambo, Robert M; Pietiläinen, Kirsi H; Pitsiladis, Yannis P; Plange-Rhule, Jacob; Plasqui, Guy; Prentice, Ross L; Rabinovich, Roberto A; Racette, Susan B; Raichlen, David A; Ravussin, Eric; Reynolds, Rebecca M; Roberts, Susan B; Schuit, Albertine J; Sjödin, Anders M; Stice, Eric; Urlacher, Samuel S; Valenti, Giulio; Van Etten, Ludo M; Van Mil, Edgar A; Wells, Jonathan CK; Wilson, George; Wood, Brian M; Yanovski, Jack; Yoshida, Tsukasa; Zhang, Xueying; Murphy-Alford, Alexia J; Loechl, Cornelia; Luke, Amy H; Rood, Jennifer; Schoeller, Dale A; Westerterp, Klaas R; Wong, William W; Speakman, John R; Consortium§, IAEA DLW Database
Source
Science. 373(6556)
Subject
Language
Abstract
Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.