학술논문
In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis
Document Type
article
Author
Africa, Jonathan A; Behling, Cynthia A; Brunt, Elizabeth M; Zhang, Nan; Luo, Yunjun; Wells, Alan; Hou, Jiayi; Belt, Patricia H; Kohil, Rohit; Lavine, Joel E; Molleston, Jean P; Newton, Kimberly P; Whitington, Peter F; Schwimmer, Jeffrey B; Abrams, Stephanie H; Barlow, Sarah; Himes, Ryan; Krisnamurthy, Rajesh; Maldonado, Leanel; Mahabir, Rory; Carr, April; Bernstein, Kimberlee; Bramlage, Kristin; Cecil, Kim; DeVore, Stephanie; Kohli, Rohit; Lake, Kathleen; Podberesky, Daniel; Towbin, Alex; Xanthakos, Stavra; Behr, Gerald; Lefkowitch, Jay H; Mencin, Ali; Reynoso, Elena; Alazraki, Adina; Cleeton, Rebecca; Cordero, Maria; Hernandez, Albert; Karpen, Saul; Munos, Jessica Cruz; Raviele, Nicholas; Vos, Miriam; Bozic, Molly; Cummings, Oscar W; Klipsch, Ann; Ragozzino, Emily; Sandrasegaran, Kumar; Subbarao, Girish; Walker, Laura; Kafka, Kimberly; Scheimann, Ann; Ito, Joy; Fishbein, Mark H; Mohammad, Saeed; Rigsby, Cynthia; Sharda, Lisa; Cattoor, Theresa; Derdoy, Jose; Freebersyser, Janet; Jain, Ajay; King, Debra; Lai, Jinping; Osmack, Pat; Siegner, Joan; Stewart, Susan; Torretta, Susan; Wriston, Kristina; Baker, Susan S; Lopez–Graham, Diana; Williams, Sonja; Zhu, Lixin; Africa, Jonathan; Awai, Hannah; Behling, Cynthia; Bross, Craig; Collins, Jennifer; Durelle, Janis; Harlow, Kathryn; Middleton, Michael; Newton, Kimberly; Paiz, Melissa; Sirlin, Claude; Ugalde-Nicalo, Patricia; Villarreal, Mariana Dominguez; Aouizerat, Bradley; Courtier, Jesse; Ferrell, Linda D; Feier, Natasha; Gill, Ryan; Langlois, Camille; Perito, Emily Rothbaum; Rosenthal, Philip; Tsai, Patrika; Cooper, Kara; Horslen, Simon
Source
Clinical Gastroenterology and Hepatology. 16(3)
Subject
Language
Abstract
Background & aimsFocal zone 1 steatosis, although rare in adults with nonalcoholic fatty liver disease (NAFLD), does occur in children with NAFLD. We investigated whether focal zone 1 steatosis and focal zone 3 steatosis are distinct subphenotypes of pediatric NAFLD. We aimed to determine associations between the zonality of steatosis and demographic, clinical, and histologic features in children with NAFLD.MethodsWe performed a cross-sectional study of baseline data from 813 children (age