학술논문
Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project
Document Type
article
Author
Florio, Andrea A; Campbell, Peter T; Zhang, Xuehong; Zeleniuch‐Jacquotte, Anne; Wactawski‐Wende, Jean; Smith‐Warner, Stephanie A; Sinha, Rashmi; Simon, Tracey G; Sesso, Howard D; Schairer, Catherine; Rosenberg, Lynn; Rohan, Thomas E; Robien, Kim; Renehan, Andrew G; Purdue, Mark P; Poynter, Jenny N; Palmer, Julie R; Newton, Christina C; Lu, Yunxia; Linet, Martha S; Liao, Linda M; Lee, I‐Min; Koshiol, Jill; Kitahara, Cari M; Kirsh, Victoria A; Hofmann, Jonathan N; Graubard, Barry I; Giovannucci, Edward; Gaziano, John M; Gapstur, Susan M; Freedman, Neal D; Demuth, Jane; Chong, Dawn Q; Chan, Andrew T; Buring, Julie E; Bradshaw, Patrick T; Freeman, Laura E Beane; McGlynn, Katherine A; Petrick, Jessica L
Source
International Journal of Cancer. 147(3)
Subject
Language
Abstract
Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined the association between waist and hip circumference with risk of PLC overall and by histologic type-hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project is a consortium of prospective cohort studies that include data from 1,167,244 individuals (PLC n = 2,208, HCC n = 1,154, ICC n = 335). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Waist circumference, per 5 cm increase, was associated with an 11% increased PLC risk (HR = 1.11, 95%CI: 1.09-1.14), including when adjusted for hip circumference (HR = 1.12, 95%CI: 1.08-1.17) and also when restricted to individuals in a normal body mass index (BMI) range (18.5 to