학술논문
Lymphoma and multiple myeloma in cohorts of persons exposed to ionising radiation at a young age
Document Type
article
Author
Little, Mark P; Wakeford, Richard; Zablotska, Lydia B; Borrego, David; Griffin, Keith T; Allodji, Rodrigue S; de Vathaire, Florent; Lee, Choonsik; Brenner, Alina V; Miller, Jeremy S; Campbell, David; Sadetzki, Siegal; Doody, Michele M; Holmberg, Erik; Lundell, Marie; Adams, Michael Jacob; French, Benjamin; Linet, Martha S; Berrington de Gonzalez, Amy
Source
Leukemia. 35(10)
Subject
Language
Abstract
There is limited evidence that non-leukaemic lymphoid malignancies are radiogenic. As radiation-related cancer risks are generally higher after childhood exposure, we analysed pooled lymphoid neoplasm data in nine cohorts first exposed to external radiation aged 0.4). In six cohorts with estimates of lymphatic tissue dose, borderline significant increased risks (p-trend = 0.02-0.07) were observed for NHL + CLL, NHL, and CLL. Further pooled epidemiological studies are needed with longer follow-up, central outcome review by expert hematopathologists, and assessment of radiation doses to lymphoid tissues.