학술논문
White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury.
Document Type
article
Author
Dennis, Emily L; Caeyenberghs, Karen; Hoskinson, Kristen R; Merkley, Tricia L; Suskauer, Stacy J; Asarnow, Robert F; Babikian, Talin; Bartnik-Olson, Brenda; Bickart, Kevin; Bigler, Erin D; Ewing-Cobbs, Linda; Figaji, Anthony; Giza, Christopher C; Goodrich-Hunsaker, Naomi J; Hodges, Cooper B; Hovenden Aa, Elizabeth S; Irimia, Andrei; Königs, Marsh; Levin, Harvey S; Lindsey, Hannah M; Max, Jeffrey E; Newsome, Mary R; Olsen, Alexander; Ryan, Nicholas P; Schmidt, Adam T; Spruiell, Matthew S; Wade, Benjamin Sc; Ware, Ashley L; Watson, Christopher G; Wheeler, Anne L; Yeates, Keith Owen; Zielinski, Brandon A; Kochunov, Peter; Jahanshad, Neda; Thompson, Paul M; Tate, David F; Wilde, Elisabeth A
Source
Neurology. 97(3)
Subject
Language
Abstract
ObjectiveOur study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine associations between WM organization and neurobehavioral outcomes.MethodsData from ten previously enrolled, existing cohorts recruited from local hospitals and clinics were shared with the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric msTBI working group. We conducted a coordinated analysis of diffusion MRI (dMRI) data using the ENIGMA dMRI processing pipeline.ResultsFive hundred and seven children and adolescents (244 with complicated mild to severe TBI [msTBI] and 263 controls) were included. Patients were clustered into three post-injury intervals: acute/subacute -