학술논문

A High-Throughput Microfluidic Cell Sorter Using a Three-Dimensional Coupled Hydrodynamic-Dielectrophoretic Pre-Focusing Module.
Document Type
article
Source
Micromachines. 14(10)
Subject
dielectrophoresis
high-throughput cell sorting
hydrodynamic-dielectrophoretic 3D cell pre-focusing
microfluidics
theoretical and numerical modeling
Language
Abstract
Dielectrophoresis (DEP) is a powerful tool for label-free sorting of cells, even those with subtle differences in morphological and dielectric properties. Nevertheless, a major limitation is that most existing DEP techniques can efficiently sort cells only at low throughputs (150,000 cells min-1) with 90% separation purity, 85% cell recovery, and no negative impact on cell viability.