학술논문
Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Document Type
article
Author
Adelman, John P; Clapham, David E; Hibino, Hiroshi; Inanobe, Atsushi; Jan, Lily Y; Karschin, Andreas; Kubo, Yoshihiro; Kurachi, Yoshihisa; Lazdunski, Michel; Miki, Takashi; Nichols, Colin G; Palmer, Lawrence G; Pearson, Wade L; Sackin, Henry; Seino, Susumu; Slesinger, Paul A; Tucker, Stephen; Vandenberg, Carol A
Source
IUPHAR/BPS Guide to Pharmacology CITE. 2019(4)
Subject
Language
Abstract
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).