학술논문
Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients.
Document Type
article
Author
Bodansky, Aaron; Wang, Chung-Yu; Saxena, Aditi; Mitchell, Anthea; Kung, Andrew; Takahashi, Saki; Anglin, Khamal; Hoh, Rebecca; Lu, Scott; Goldberg, Sarah; Romero, Justin; Tran, Brandon; Kirtikar, Raushun; Grebe, Halle; So, Matthew; Hsue, Priscilla; Hellmuth, Joanna; Kelly, J; Henrich, Timothy; Greenhouse, Bryan; Martin, Jeffrey; Anderson, Mark; Deeks, Steven; Derisi, Joseph; Peluso, Michael; Durstenfeld, Matthew; Huang, Beatrice
Source
JCI Insight. 8(11)
Subject
Language
Abstract
Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in severity of SARS-CoV-2 infection and certain other post-COVID sequelae, their potential role in long COVID is important to investigate. Here, we apply a well-established, unbiased, proteome-wide autoantibody detection technology (T7 phage-display assay with immunoprecipitation and next-generation sequencing, PhIP-Seq) to a robustly phenotyped cohort of 121 individuals with long COVID, 64 individuals with prior COVID-19 who reported full recovery, and 57 pre-COVID controls. While a distinct autoreactive signature was detected that separated individuals with prior SARS-CoV-2 infection from those never exposed to SARS-CoV-2, we did not detect patterns of autoreactivity that separated individuals with long COVID from individuals fully recovered from COVID-19. These data suggest that there are robust alterations in autoreactive antibody profiles due to infection; however, no association of autoreactive antibodies and long COVID was apparent by this assay.