학술논문

Brain organoids, consciousness, ethics and moral status
Document Type
article
Source
Subject
Biochemistry and Cell Biology
Biological Sciences
Stem Cell Research - Embryonic - Human
Neurosciences
Stem Cell Research - Induced Pluripotent Stem Cell - Human
Stem Cell Research - Induced Pluripotent Stem Cell
Stem Cell Research
1.1 Normal biological development and functioning
Neurological
Mental health
Humans
Consciousness
Moral Status
Brain
Pluripotent Stem Cells
Organoids
Brain organoids
Ethics
Stem cells
Brain oscillations
Moral status
Paediatrics and Reproductive Medicine
Developmental Biology
Biochemistry and cell biology
Language
Abstract
Advances in the field of human stem cells are often a source of public and ethical controversy. Researchers must frequently balance diverse societal perspectives on questions of morality with the pursuit of medical therapeutics and innovation. Recent developments in brain organoids make this challenge even more acute. Brain organoids are a new class of brain surrogate generated from human pluripotent stem cells (hPSCs). They have gained traction as a model for studying the intricacies of the human brain by using advancements in stem cell biology to recapitulate aspects of the developing human brain in vitro. However, recent observation of neural oscillations spontaneously emerging from these organoids raises the question of whether brain organoids are or could become conscious. At the same time, brain organoids offer a potentially unique opportunity to scientifically understand consciousness. To address these issues, experimental biologists, philosophers, and ethicists united to discuss the possibility of consciousness in human brain organoids and the consequent ethical and moral implications.