학술논문
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
Document Type
article
Author
Hoffmann, Thomas J; Passarelli, Michael N; Graff, Rebecca E; Emami, Nima C; Sakoda, Lori C; Jorgenson, Eric; Habel, Laurel A; Shan, Jun; Ranatunga, Dilrini K; Quesenberry, Charles P; Chao, Chun R; Ghai, Nirupa R; Aaronson, David; Presti, Joseph; Nordström, Tobias; Wang, Zhaoming; Berndt, Sonja I; Chanock, Stephen J; Mosley, Jonathan D; Klein, Robert J; Middha, Mridu; Lilja, Hans; Melander, Olle; Kvale, Mark N; Kwok, Pui-Yan; Schaefer, Catherine; Risch, Neil; Van Den Eeden, Stephen K; Witte, John S
Source
Nature communications. 8(1)
Subject
Language
Abstract
Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa-such as genetics-can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P