학술논문
Clonal haematopoiesis and risk of chronic liver disease.
Document Type
article
Author
Dichtel, Laura; Griffin, Gabriel; Uddin, Md; Gibson, Christopher; Kovalcik, Veronica; Lin, Amy; McConkey, Marie; Vromman, Amelie; Sellar, Rob; Kim, Peter; Agrawal, Mridul; Weinstock, Joshua; Long, Michelle; Yu, Bing; Banerjee, Rajarshi; Nicholls, Rowan; Dennis, Andrea; Kelly, Matt; Loh, Po-Ru; McCarroll, Steve; Boerwinkle, Eric; Vasan, Ramachandran; Jaiswal, Siddhartha; Johnson, Andrew; Chung, Raymond; Corey, Kathleen; Levy, Daniel; Ballantyne, Christie; Ebert, Benjamin; Natarajan, Pradeep; Wong, Waihay; Emdin, Connor; Bick, Alexander; Zekavat, Seyedeh; Niroula, Abhishek; Pirruccello, James
Source
Nature. 616(7958)
Subject
Language
Abstract
Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P