학술논문
Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium
Document Type
article
Author
Jensen, Majken K; Jensen, Richard A; Mukamal, Kenneth J; Guo, Xiuqing; Yao, Jie; Sun, Qi; Cornelis, Marilyn; Liu, Yongmei; Chen, Ming-Huei; Kizer, Jorge R; Djoussé, Luc; Siscovick, David S; Psaty, Bruce M; Zmuda, Joseph M; Rotter, Jerome I; Garcia, Melissa; Harris, Tamara; Chen, Ida; Goodarzi, Mark O; Nalls, Michael A; Keller, Margaux; Arnold, Alice M; Newman, Anne B; Hoogeveen, Ron C; Rexrode, Kathryn M; Rimm, Eric B; Hu, Frank B; Ramachandran, Vasan S; Katz, Ronit; Pankow, James S; Ix, Joachim H
Source
Human Molecular Genetics. 26(11)
Subject
Language
Abstract
Plasma fetuin-A is associated with type 2 diabetes, and AHSG, the gene encoding fetuin-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome. Thus far, unbiased investigations of the genetic determinants of plasma fetuin-A concentrations have not been conducted. We searched for single nucleotide polymorphisms (SNPs) related to fetuin-A concentrations by a genome-wide association study in six population-based studies. We examined the association of fetuin-A levels with ∼ 2.5 million genotyped and imputed SNPs in 9,055 participants of European descent and 2,119 African Americans. In both ethnicities, the strongest associations were centered in a region with a high degree of LD near the AHSG locus. Among 136 genome-wide significant (P