학술논문
REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers
Document Type
article
Author
Saunders‐Pullman, Rachel; Alcalay, Roy N; Mirelman, Anat; Wang, Cuiling; San Luciano, Marta; Ortega, Roberto A; Glickman, Amanda; Raymond, Deborah; Mejia‐Santana, Helen; Doan, Nancy; Johannes, Brooke; Yasinovsky, Kira; Ozelius, Laurie; Clark, Lorraine; Orr‐Utreger, Avi; Marder, Karen; Giladi, Nir; Bressman, Susan B; Consortium, the AJ LRRK2
Source
Movement Disorders. 30(13)
Subject
Language
Abstract
BackgroundRapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established.MethodsOne hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire.ResultsCut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05).ConclusionsA lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.