학술논문
Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.
Document Type
article
Author
Gong, Jessica; Harris, Katie; Lipnicki, Darren; Castro-Costa, Erico; Lima-Costa, Maria; Diniz, Breno; Xiao, Shifu; Lipton, Richard; Katz, Mindy; Wang, Cuiling; Preux, Pierre-Marie; Guerchet, Maëlenn; Gbessemehlan, Antoine; Ritchie, Karen; Ancelin, Marie-Laure; Skoog, Ingmar; Najar, Jenna; Sterner, Therese; Scarmeas, Nikolaos; Yannakoulia, Mary; Kosmidis, Mary; Guaita, Antonio; Rolandi, Elena; Davin, Annalisa; Gureje, Oye; Trompet, Stella; Gussekloo, Jacobijn; Riedel-Heller, Steffi; Pabst, Alexander; Röhr, Susanne; Shahar, Suzana; Singh, Devinder; Rivan, Nurul; Boxtel, Martin; Köhler, Sebastian; Ganguli, Mary; Chang, Chung-Chou; Jacobsen, Erin; Ding, Ding; Zhao, Qianhua; Xiao, Zhenxu; Narazaki, Kenji; Chen, Tao; Chen, Sanmei; Ng, Tze; Gwee, Xinyi; Numbers, Katya; Mather, Karen; Scazufca, Marcia; Lobo, Antonio; De-la-Cámara, Concepción; Lobo, Elena; Sachdev, Perminder; Brodaty, Henry; Hackett, Maree; Peters, Sanne; Woodward, Mark; Haan, Mary
Source
Alzheimers & Dementia: The Journal of the Alzheimers Association. 19(8)
Subject
Language
Abstract
INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.