학술논문
Multiethnic Genome-wide Association Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Document Type
article
Author
Pollack, Samuela; Igo, Robert P; Jensen, Richard A; Christiansen, Mark; Li, Xiaohui; Cheng, Ching-Yu; Ng, Maggie CY; Smith, Albert V; Rossin, Elizabeth J; Segrè, Ayellet V; Davoudi, Samaneh; Tan, Gavin S; Chen, Yii-Der Ida; Kuo, Jane Z; Dimitrov, Latchezar M; Stanwyck, Lynn K; Meng, Weihua; Hosseini, S Mohsen; Imamura, Minako; Nousome, Darryl; Kim, Jihye; Hai, Yang; Jia, Yucheng; Ahn, Jeeyun; Leong, Aaron; Shah, Kaanan; Park, Kyu Hyung; Guo, Xiuqing; Ipp, Eli; Taylor, Kent D; Adler, Sharon G; Sedor, John R; Freedman, Barry I; Group, DCCT EDIC Research Group Family Investigation of Nephropathy and Diabetes-Eye Research; Lee, I-Te; Sheu, Wayne H-H; Kubo, Michiaki; Takahashi, Atsushi; Hadjadj, Samy; Marre, Michel; Tregouet, David-Alexandre; Mckean-Cowdin, Roberta; Varma, Rohit; McCarthy, Mark I; Groop, Leif; Ahlqvist, Emma; Lyssenko, Valeriya; Agardh, Elisabet; Morris, Andrew; Doney, Alex SF; Colhoun, Helen M; Toppila, Iiro; Sandholm, Niina; Groop, Per-Henrik; Maeda, Shiro; Hanis, Craig L; Penman, Alan; Chen, Ching J; Hancock, Heather; Mitchell, Paul; Craig, Jamie E; Chew, Emily Y; Paterson, Andrew D; Grassi, Michael A; Palmer, Colin; Bowden, Donald W; Yaspan, Brian L; Siscovick, David; Cotch, Mary Frances; Wang, Jie Jin; Burdon, Kathryn P; Wong, Tien Y; Klein, Barbara EK; Klein, Ronald; Rotter, Jerome I; Iyengar, Sudha K; Price, Alkes; Sobrin, Lucia
Source
Diabetes. 68(2)
Subject
Language
Abstract
To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a P value