학술논문
Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort
Document Type
article
Author
Tejwani, Vickram; Fawzy, Ashraf; Putcha, Nirupama; Castaldi, Peter J; Cho, Michael H; Pratte, Katherine A; Bhatt, Surya P; Lynch, David A; Humphries, Stephen M; Kinney, Gregory L; D’Alessio, Franco R; Hansel, Nadia N; Crapo, James D; Silverman, Edwin K; Make, Barry J; Regan, Elizabeth A; Beaty, Terri; Begum, Ferdouse; Cho, Michael; DeMeo, Dawn L; Boueiz, Adel R; Foreman, Marilyn G; Halper-Stromberg, Eitan; Hayden, Lystra P; Hersh, Craig P; Hetmanski, Jacqueline; Hobbs, Brian D; Hokanson, John E; Laird, Nan; Lange, Christoph; Lutz, Sharon M; McDonald, Merry-Lynn; Parker, Margaret M; Prokopenko, Dmitry; Qiao, Dandi; Regan, Elizabeth; Sakornsakolpat, Phuwanat; Wan, Emily S; Won, Sungho; Centeno, Juan Pablo; Charbonnier, Jean-Paul; Coxson, Harvey O; Galban, Craig J; Han, MeiLan K; Hoffman, Eric A; Humphries, Stephen; Jacobson, Francine L; Judy, Philip F; Kazerooni, Ella A; Kluiber, Alex; Nardelli, Pietro; Newell, John D; Notary, Aleena; Oh, Andrea; Ross, James C; San Jose Estepar, Raul; Schroeder, Joyce; Sieren, Jered; Stoel, Berend C; Tschirren, Juerg; Van Beek, Edwin; Ginneken, Bramvan; van Rikxoort, Eva; Sanchez-Ferrero, Gonzalo Vegas; Veitel, Lucas; Washko, George R; Wilson, Carla G; Jensen, Robert; Everett, Douglas; Crooks, Jim; Pratte, Katherine; Strand, Matt; Kinney, Gregory; Young, Kendra A; Bon, Jessica; Diaz, Alejandro A; Make, Barry; Murray, Susan; Soler, Xavier; Bowler, Russell P; Kechris, Katerina; Banaei-Kashani, Farnoush; Curtis, Jeffrey L; Pernicano, Perry G; Hanania, Nicola; Atik, Mustafa; Boriek, Aladin; Guntupalli, Kalpatha; Guy, Elizabeth
Source
CHEST Journal. 160(4)
Subject
Language
Abstract
BackgroundAttenuation of transforming growth factor β by blocking angiotensin II has been shown to reduce emphysema in a murine model. General population studies have demonstrated that the use of angiotensin converting enzyme inhibitors (ACEis) and angiotensin-receptor blockers (ARBs) is associated with reduction of emphysema progression in former smokers and that the use of ACEis is associated with reduction of FEV1 progression in current smokers.Research questionIs use of ACEi and ARB associated with less progression of emphysema and FEV1 decline among individuals with COPD or baseline emphysema?MethodsFormer and current smokers from the Genetic Epidemiology of COPD Study who attended baseline and 5-year follow-up visits, did not change smoking status, and underwent chest CT imaging were included. Adjusted linear mixed models were used to evaluate progression of adjusted lung density (ALD), percent emphysema (%total lung volume