학술논문
Sensitivity of the Social Behavior Observer Checklist to Early Symptoms of Patients With Frontotemporal Dementia.
Document Type
article
Author
Toller, Gianina; Cobigo, Yann; Ljubenkov, Peter A; Appleby, Brian S; Dickerson, Bradford C; Domoto-Reilly, Kimiko; Fong, Jamie C; Forsberg, Leah K; Gavrilova, Ralitza H; Ghoshal, Nupur; Heuer, Hilary W; Knopman, David S; Kornak, John; Lapid, Maria I; Litvan, Irene; Lucente, Diane E; Mckenzie, Ian R; McGinnis, Scott M; Miller, Bruce L; Pedraza, Otto; Rojas, Julio C; Staffaroni, Adam M; Wong, Bonnie; Wszolek, Zbigniew K; Boeve, Brad F; Boxer, Adam L; Rosen, Howard J; Rankin, Katherine P; ALLFTD research consortium
Source
Neurology. 99(5)
Subject
Language
Abstract
Background and objectivesChanges in social behavior are common symptoms of frontotemporal lobar degeneration (FTLD) and Alzheimer's disease syndromes. For early identification of individual patients and differential diagnosis, sensitive clinical measures are required that are able to assess patterns of behaviors and detect syndromic differences in both asymptomatic and symptomatic stages. We investigated whether the examiner-based Social Behavior Observer Checklist (SBOCL) is sensitive to early behavior changes and reflects disease severity within and between neurodegenerative syndromes.MethodsAsymptomatic individuals and neurodegenerative disease patients were selected from the multisite ALLFTD cohort study. In a sample of participants with at least one timepoint of SBOCL data, we investigated whether the Disorganized, Reactive, and Insensitive subscales of the SBOCL change as a function of disease stage within and between these syndromes. In a longitudinal subsample with both SBOCL and neuroimaging data, we examined whether change over time on each subscale corresponds to progressive gray matter atrophy.Results1082 FTLD mutation carriers and non-carriers were enrolled (282 asymptomatic, 341 behavioral variant frontotemporal dementia, 114 semantic and 95 non-fluent variant primary progressive aphasia, 137 progressive supranuclear palsy, 113 Alzheimer's clinical syndrome). The Disorganized score increased between asymptomatic to very mild (p=0.016, estimate=-1.10, 95%CI=[-1.99, -0.22]), very mild to mild (p=0.013, -1.17, [-2.08, -0.26]), and mild to moderate/severe (p