학술논문
Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm
Document Type
article
Author
Jobe, Alan H; Caplan, Michael S; Polin, Richard A; Laptook, Abbot R; Hensman, Angelita M; Vieira, Elisa; Little, Emilee; Johnson, Katharine; Alksninis, Barbara; Keszler, Mary Lenore; Knoll, Andrea M; Leach, Theresa M; McGowan, Elisabeth C; Watson, Victoria E; Walsh, Michele C; Fanaroff, Avroy A; Payne, Allison; Wilson-Costello, Deanne E; Newman, Nancy S; Siner, Bonnie S; Zadell, Arlene; DiFiore, Julie; Bhola, Monika; Friedman, Harriet G; Yalcinkaya, Gulgun; Goldberg, Ronald N; Cotten, C Michael; Gustafson, Kathryn E; Goldstein, Ricki F; Ashley, Patricia; Auten, Kathy J; Fisher, Kimberley A; Foy, Katherine A; Freedman, Sharon F; Lohmeyer, Melody B; Malcolm, William F; Wallace, David K; Carlton, David P; Stoll, Barbara J; Adams-Chapman, Ira; Buchter, Susie; Piazza, Anthony J; Carter, Sheena; Fritz, Sobha; Hale, Ellen C; Hutchinson, Amy K; LaRossa, Maureen Mulligan; Loggins, Yvonne; Bottcher, Diane; Higgins, Rosemary D; Archer, Stephanie Wilson; Poindexter, Brenda B; Sokol, Gregory M; Harmon, Heidi M; Papile, Lu-Ann; Hines, Abbey C; Wilson, Leslie D; Herron, Dianne E; Smiley, Lucy; Granger, Douglas A; Kennedy, Kathleen A; Tyson, Jon E; Duncan, Andrea F; Dempsey, Allison G; John, Janice; Jones, Patrick M; Lillie, M Layne; Siddiki, Saba; Sperry, Daniel K; Blaisdell, Carol J; Das, Abhik; Wallace, Dennis; Gantz, Marie G; O’Donnell Auman, Jeanette; Hammond, Jane A; Newman, Jamie E; Poole, W Kenneth; Van Meurs, Krisa P; Stevenson, David K; Ball, M Bethany; DeAnda, Maria Elena; Goodlin, Gabrielle T; Frantz, Ivan D; Fiascone, John M; Kurfiss, Anne; MacKinnon, Brenda L; Nylen, Ellen; Brussa, Ana; Sibley, Cecelia; Carlo, Waldemar A; Ambalavanan, Namasivayam; Collins, Monica V; Cosby, Shirley S; Phillips, Vivien A; Domanovich, Kristy; Whitley, Sally; Smith, Leigh Ann; Kiser, Carin R; Finer, Neil N
Source
Pediatric Research. 93(3)
Subject
Language
Abstract
BackgroundExtremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.MethodsThis secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.ResultsCortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p