학술논문
Anthropometric Measures, Body Mass Index, and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)
Document Type
article
Author
Arslan, Alan A; Helzlsouer, Kathy J; Kooperberg, Charles; Shu, Xiao-Ou; Steplowski, Emily; Bueno-de-Mesquita, H Bas; Fuchs, Charles S; Gross, Myron D; Jacobs, Eric J; Lacroix, Andrea Z; Petersen, Gloria M; Stolzenberg-Solomon, Rachael Z; Zheng, Wei; Albanes, Demetrius; Amundadottir, Laufey; Bamlet, William R; Barricarte, Aurelio; Bingham, Sheila A; Boeing, Heiner; Boutron-Ruault, Marie-Christine; Buring, Julie E; Chanock, Stephen J; Clipp, Sandra; Gaziano, J Michael; Giovannucci, Edward L; Hankinson, Susan E; Hartge, Patricia; Hoover, Robert N; Hunter, David J; Hutchinson, Amy; Jacobs, Kevin B; Kraft, Peter; Lynch, Shannon M; Manjer, Jonas; Manson, Joann E; McTiernan, Anne; McWilliams, Robert R; Mendelsohn, Julie B; Michaud, Dominique S; Palli, Domenico; Rohan, Thomas E; Slimani, Nadia; Thomas, Gilles; Tjønneland, Anne; Tobias, Geoffrey S; Trichopoulos, Dimitrios; Virtamo, Jarmo; Wolpin, Brian M; Yu, Kai; Zeleniuch-Jacquotte, Anne; Patel, Alpa V
Source
JAMA Internal Medicine. 170(9)
Subject
Language
Abstract
BackgroundObesity has been proposed as a risk factor for pancreatic cancer.MethodsPooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, or = 35.0). Models were adjusted for potential confounders.ResultsIn all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; P(trend) < .001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; P(trend) < .03), and in women it was 1.34 (95% CI, 1.05-1.70; P(trend) = .01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; P(trend) = .003) but less so in men.ConclusionsThese findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.