학술논문
Local Control For High-Grade Nonrhabdomyosarcoma Soft Tissue Sarcoma Assigned to Radiation Therapy on ARST0332: A Report From the Childrens Oncology Group
Document Type
article
Author
Million, Lynn; Hayes-Jordan, Andrea; Chi, Yueh-Yun; Donaldson, Sarah S; Wolden, Suzanne; Morris, Carol; Terezakis, Stephanie; Laurie, Fran; Morano, Karen; Fitzgerald, TJ; Yock, Torunn I; Rodeberg, David A; Anderson, James R; Speights, Rose Anne; Black, Jennifer O; Coffin, Cheryl; McCarville, Mary Beth; Kao, Simon C; Hawkins, Douglas S; Spunt, Sheri L; Randall, R Lor
Source
International Journal of Radiation Oncology • Biology • Physics. 110(3)
Subject
Language
Abstract
PurposeThe ARST0332 trial for pediatric and young adults with nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) used risk-based treatment including primary resection with lower-than-standard radiation doses to optimize local control (LC) while minimizing long-term toxicity in those requiring radiation therapy (RT). RT for high-grade NRSTS was based on extent of resection (R0: negative margins, R1: microscopic margins, R2/U: gross disease/unresectable); those with >5 cm tumors received chemotherapy (CT; ifosfamide/doxorubicin). This analysis evaluates LC for patients assigned to RT and prognostic factors associated with local recurrence (LR).Methods and materialsPatients aged 5 cm tumor (arm C); or neoadjuvant RT (45 Gy)/CT plus delayed surgery, CT, and postoperative boost to 10.8 Gy R0