학술논문

Guardians of the Gut: Enteric Defensins
Document Type
article
Source
Frontiers in Microbiology. 8(APR)
Subject
Microbiology
Biological Sciences
Biomedical and Clinical Sciences
Digestive Diseases
Autoimmune Disease
Prevention
Inflammatory Bowel Disease
1.1 Normal biological development and functioning
Underpinning research
Oral and gastrointestinal
enteric alpha defensins
mucosal immunity
paneth cells
IBD microbiota research
antimicrobial peptide
Environmental Science and Management
Soil Sciences
Medical microbiology
Language
Abstract
Enteric defensins likely play a key role in the management of the human microbiome throughout development. The functional and mechanistic diversity of defensins is much greater than was initially thought. Defensin expression and overall Paneth cell physiology likely plays a key role in the development of colitis and other inflammatory or dysbiotic diseases of the gut. As our understanding of enteric defensins grows, their potential as tools of clinical intervention becomes more apparent. In this review, we focus on the function and activity of Paneth Cell defensins and highlight their role in disease.