학술논문

Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI.
Document Type
article
Source
Subject
Humans
Recovery of Function
Nerve Regeneration
Neuronal Plasticity
Child
Child
Preschool
Infant
Infant
Newborn
Brain Injuries
Traumatic
Development
Pediatric TBI
Plasticity
Traumatic brain injury
Traumatic Brain Injury (TBI)
Pediatric
Physical Injury - Accidents and Adverse Effects
Neurosciences
Traumatic Head and Spine Injury
Rehabilitation
Brain Disorders
Unintentional Childhood Injury
Neurological
Clinical Sciences
Psychology
Neurology & Neurosurgery
Language
Abstract
Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.