학술논문
Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”
Document Type
article
Author
Bilican, Bilada; Serio, Andrea; Barmada, Sami J; Nishimura, Agnes Lumi; Sullivan, Gareth J; Carrasco, Monica; Phatnani, Hemali P; Puddifoot, Clare A; Story, David; Fletcher, Judy; Park, In-Hyun; Friedman, Brad A; Daley, George Q; Wyllie, David JA; Hardingham, Giles E; Wilmut, Ian; Finkbeiner, Steven; Maniatis, Tom; Shaw, Christopher E; Chandran, Siddharthan
Source
Science Translational Medicine. 5(188)
Subject
Language
Abstract
Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.