학술논문
Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans
Document Type
article
Author
Wang, Heming; Cade, Brian E; Sofer, Tamar; Sands, Scott A; Chen, Han; Browning, Sharon R; Stilp, Adrienne M; Louie, Tin L; Thornton, Timothy A; Johnson, W Craig; Below, Jennifer E; Conomos, Matthew P; Evans, Daniel S; Gharib, Sina A; Guo, Xiuqing; Wood, Alexis C; Mei, Hao; Yaffe, Kristine; Loredo, Jose S; Ramos, Alberto R; Barrett-Connor, Elizabeth; Ancoli-Israel, Sonia; Zee, Phyllis C; Arens, Raanan; Shah, Neomi A; Taylor, Kent D; Tranah, Gregory J; Stone, Katie L; Hanis, Craig L; Wilson, James G; Gottlieb, Daniel J; Patel, Sanjay R; Rice, Ken; Post, Wendy S; Rotter, Jerome I; Sunyaev, Shamil R; Cai, Jianwen; Lin, Xihong; Purcell, Shaun M; Laurie, Cathy C; Saxena, Richa; Redline, Susan; Zhu, Xiaofeng
Source
Human Molecular Genetics. 28(4)
Subject
Language
Abstract
Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Its prevalence and severity vary across ancestral background. Although OSA traits are heritable, few genetic associations have been identified. To identify genetic regions associated with OSA and improve statistical power, we applied admixture mapping on three primary OSA traits [the apnea hypopnea index (AHI), overnight average oxyhemoglobin saturation (SaO2) and percentage time SaO2