학술논문
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.
Document Type
article
Author
Tang, Monica; Elicker, Brett M; Henry, Travis; Gierada, David S; Schiebler, Mark L; Huang, Brendan K; Peters, Michael C; Castro, Mario; Hoffman, Eric A; Fain, Sean B; Ash, Samuel Y; Choi, Jiwoong; Hall, Chase; Phillips, Brenda R; Mauger, David T; Denlinger, Loren C; Jarjour, Nizar N; Israel, Elliot; Phipatanakul, Wanda; Levy, Bruce D; Wenzel, Sally E; Bleecker, Eugene R; Woodruff, Prescott G; Fahy, John V; Dunican, Eleanor M
Source
American Journal of Respiratory and Critical Care Medicine. 205(9)
Subject
Language
Abstract
Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug phenotype. Objectives: To determine if mucus plugs are a persistent asthma phenotype and if changes in mucus plugs over time associate with changes in lung function. Methods: In a longitudinal analysis of baseline and Year 3 CT lung scans in SARP-3 participants, radiologists generated mucus plug scores to assess mucus plug persistence over time. Changes in mucus plug score were analyzed in relation to changes in lung function and CT air trapping measures. Measurements and Main Results: In 164 participants, the mean (range) mucus plug score was similar at baseline and Year 3 (3.4 [0-20] vs. 3.8 [0-20]). Participants and bronchopulmonary segments with a baseline plug were more likely to have plugs at Year 3 than those without baseline plugs (risk ratio, 2.8; 95% confidence interval [CI], 2.0-4.1; P