학술논문
Risk factors for peripartum blood transfusion in South Africa: a case‐control study
Document Type
article
Author
Bloch, Evan M; Ingram, Charlotte; Hull, Jennifer; Fawcus, Susan; Anthony, John; Green‐Thompson, Randolph; Crookes, Robert L; Ngcobo, Solomuzi; Creel, Darryl V; Courtney, Lauren; Bellairs, Greg RM; Murphy, Edward L; Study‐III, for the South Africa Program of the NHLBI Recipient Epidemiology and Donor Evaluation
Source
Transfusion. 58(9)
Subject
Language
Abstract
BackgroundObstetric hemorrhage (OH) and access to peripartum blood transfusion remains a global health challenge. The rates of peripartum transfusion in South Africa exceed those in high-income countries despite comparable rates of OH. We sought to evaluate factors associated with peripartum transfusion.Study design and methodsA case-control study was conducted at four large South African hospitals. Transfused peripartum women (cases) and nontransfused controls were stratum matched 1:2 by hospital and delivery date. Data on obstetric, transfusion, and human immunodeficiency virus (HIV) history were abstracted from medical records. Blood was obtained for laboratory evaluation. We calculated unadjusted and adjusted odds ratios (ORs) for transfusion using logistic regression.ResultsA total of 1200 transfused cases and 2434 controls were evaluated. Antepartum hemorrhage (OR, 197.95; 95% confidence interval [CI], 104.27-375.78), hemorrhage with vaginal delivery (OR, 136.46; 95% CI, 75.87-245.18), prenatal anemia (OR, 22.76; 95% CI, 12.34-41.93 for prenatal hemoglobin level